Jessica Williamson
From WikidChem
Jess was a graduate student in the Miranker Lab in the department of Molecular Biophysics & Biochemistry.
Contents |
Current
Postdoctoral Fellow
Laboratory of James Chou
Harvard Medical School, Boston, MA
Education
Yale University, Ph.D., Molecular Biophysics & Biochemistry, May 2008
Colby College, B.A., Chemistry, 1999
Research Experience
Yale University, New Haven, CT, September 2001-March 2008
Dissertation: "Determination of Transient Structure in Early Intermediates of Islet Amyloid Polypeptide Fiber Assembly"
Characterized the dynamics and transient structure of pre-fiber islet amyloid polypeptide (IAPP) using heteronuclear NMR spectroscopy. Correlated structures in solution and on lipid membranes with amyloid assembly. Developed an expression and purification method to produce wiltype IAPP.
Dana-Farber Cancer Institute, Boston, MA, July 1999-August 2001
Laboratory Technician, Molecular Diagnostics Laboratory
Supervisor: Dr. Edward A. Fox
Worked in a core facility laboratory on project-based collaborations in human cancer genetics. Sequenced patient DNA and conducted whole-cell genetic profiling using serial analysis of gene expression (SAGE).
Colby College, Waterville, ME, September 1998-May 1999
Undergraduate Student, Department of Chemistry
Advisor: Dr. Shari U. Dunham
Purified a low-molecular weight chromium-binding peptide for future NMR study.
Publications
J. A. Williamson and A. D. Miranker. Direct detection of transient α-helical states in islet amyloid polypeptide. Protein Sci. 16, 110-7 (2007).
M. Lepourcelet, L. Tou, L. Cai, J. Sawada, A. J. Lazar, J. N. Glickman, J. A. Williamson, A. D. Everett, M. Redston, E. A. Fox, Y. Nakatani, R A. Shivdasani. Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development. 132, 415-27 (2005).
C. E. Atreya, E. F. Johnson, J. Williamson, S. Y. Chang, P. H. Liang, K. S Anderson. Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis. J. Biol Chem. 278, 28901-11 (2003).
